A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of <i>o</i>-Chloro Benzoates by KCl, Arynes, CO₂, and Chloroalkanes

Abstract

A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO₂ has been reported for the first time, enabling the incorporation of both chloro and CO₂ into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.