Concepedia

Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction

Nathalie Mougenot, Delphine Mika, Gábor Czibik, E. Marcos, Shariq Abid, Amal Houssaïni, Benjamin Vallin, Aziz Guellich, Hind Mehel, Daigo Sawaki,

Cardiovascular Research · 2018 · 40 citations · 24 references

DOIFull text

Open access

Abstract

Our data demonstrated an early and accelerated cardiac remodelling in AC8TG mice, leading to the development of HF and reduced lifespan. Age-related reorganization of cAMP/PKA signalling can accelerate cardiac ageing, partly through GSK3α/β phosphorylation.

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