Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach

Abstract

These findings demonstrated that TSC induced vasorelaxant effects via both endothelium-dependent and endothelium-independent pathways. The NO/sGC/cGMP pathway, ATP-sensitive K⁺ channels, Ca²⁺-activated K⁺ channels, inhibition of extracellular Ca²⁺ influx and intracellular Ca2⁺ release were probably involved in this relaxation. The vasorelaxant effects of TSC may make the greatest contribution to the reduction in high blood pressure.