Iridium‐Catalyzed Hydroxyl‐Enabled Cycloaddition of Azides and Alkynes

Abstract

Abstract A novel iridium‐catalyzed hydroxyl‐enabled cycloaddition of azides and alkynes has been developed. In the presence of catalytic amount (2 mol%) of [Ir(cod)Cl] 2 , the 2‐alkynyl phenols would engage in a regioselective cycloaddition with various azides for rapid access to diverse triazoles, and the hydroxyl group acts as directing group to enable this reaction. The process is featured mild and biocompatible reaction condition with the achievement of brevity and diversity. Furthermore, the hydroxyl group offers ample opportunity for late‐stage divergent transformations of the products. magnified image