A new indole alkaloid with anti-inflammatory from the branches of <i>Nauclea officinalis</i>

Abstract

A new indole alkaloid, 17-oxo-19-(<i>Z</i>)-naucline, and six known alkaloids 2-7 were isolated from the branches of <i>Nauclea officinalis</i>. The structure of the new compound 1 was characterised mainly by analysing its physical data including IR, 1 D, 2 D NMR, and HR-ESI-MS. Other compounds were identified by comparisons their data with those reported in the literature. Compound1, 4, 5, 6, 7 showed <i>in vitro</i> anti-inflammatory activity decrease the LPS-stimulated production of nitric oxide in RAW264.7 cell, while all compounds exhibited weak cytotoxicity against human tumour cell lines (LOVO, A549 and HepG2).