A new aryldihydronaphthalene-type lignan and other metabolites with potential anti-inflammatory activities from <i>Corispermum mongolicum</i> Iljin

Abstract

One new aryldihydronaphthalene-type lignan (<b>1</b>) together with eight known lignans (<b>2-4, 7-11</b>) as well as two caffeic-acid dimers (<b>5, 6</b>) were isolated from an ethanol extract of the whole plant of <i>Corispermum mongolicum</i> Iljin (Chenopodiaceae). The chemical structures of these compounds were determined from 1D and 2D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. This study is the first demonstration of nine compounds (<b>2</b> and <b>4</b>-<b>11</b>) isolated from the Chenopodiaceae family, with one of these (<b>3</b>) from the genus <i>Corispermum</i>. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of production of nitric oxide, tumour necrosis factor-α, and interleukin-6 in lipopolysaccharide-induced RAW 264.7 cells.