Does multilocus inherited neoplasia alleles syndrome have severe clinical expression?

Abstract

Genetic analysis of a broad cancer gene panel identified the largest series of patients with MINAS described in a single study. Overall, our data do not support the existence of more severe manifestations in double mutants at the time of diagnosis although they do confirm previous evidence of severe phenotype in biallelic <i>CHEK2</i> and other DNA repair cancer-predisposing genes.