EFFECT OF SANGUINARINE PHYTOBIOTIC, SODIUM BUTYRATE COMPARED TO AMPICILLIN ON CONTROLLING NECROTIC ENTERITIS IN BROILER CHICKENS

Abstract

This study aimed to investigate the efficacy of Sanguinarine phytobiotic, Sodium butyrate compared to ampicillin in treatment of Clostridium perfringens infection in broiler chickens with a special reference to their effects on growth performance, hematobiochemical and immunological profile. A total of 150 one-day old Cobb broiler chicks were used in this study. On day 14th of age all chicks were divided into 5 equal groups (30 each). Group (G1) non-infected, non-treated (control), G2 infected with C. perfringens, non treated, G3 infected, treated with Sodium butyrate, G4 infected and treated with Sanguinarine phytobiotic and G5 infected and treated with ampicillin. Administration of drugs in drinking water was continued for 5 days from 18-23 day of age. The results revealed that the infected broiler chickens with C. perfringens and non treated(G2) showed clinical signs of necrotic enteritis represented by loss of appetite, diarrhea, dehydration, anorexia in addition to a recorded mortality rate 30% and lesion score 80%. Moreover, significant reduction (P