Miltefosine enhances the fitness of a non-virulent drug-resistant<i>Leishmania infantum</i>strain

Abstract

The profound fitness loss of MT-deficient parasites most likely explains the low frequency of MIL-R clinical isolates. The observation that miltefosine can reverse this phenotype indicates a drug dependency of the MT-deficient parasites and emphasizes the importance of resistance profiling prior to miltefosine administration.