Noninvasive Biodegradable Nanoparticles-in-Nanofibers Single-Dose Ocular Insert: <i>In Vitro</i> , <i>Ex Vivo</i> and <i>In Vivo</i> Evaluation

Abstract

The incorporation of NPs into NFs achieved several other benefits like increasing ocular residence and contact time with conjunctival tissue, accurate dose delivery, sustaining drug release with constant rate, reducing frequency of administration, improving bioavailability along with decreasing incidence of visual and systemic side effects.