Differential responses of Lasiopodomys mandarinus and Lasiopodomys brandtii to chronic hypoxia: a cross-species brain transcriptome analysis

Abstract

L. mandarinus actively adapts its physiological functions to hypoxic conditions, for instance by increasing O₂ transport capacity and modulating O₂ consumption. In contrast, L. brandtii reacts passively to hypoxia by decreasing overall activity in order to reduce O₂ consumption. These results provide insight into hypoxia adaptation mechanisms in subterranean rodents that may be applicable to humans living at high altitudes or operating in other O₂-poor environments.