JAAD Case Reports · 2018 · 81 citations · 7 references
MedicineDermatologyImmunologyHypersensitivityImmunopharmacologyImmunotherapyAllergic Skin DiseasesAtopic DermatitisDrug-induced Skin ReactionsInflammatory DermatosesInflammatory Skin DiseasesInflammatory Skin DisordersAtopic Dermatitis PharmacotherapyAtopic Dermatitis TreatmentDrug-induced AlopeciaDrug-induced DermatitisDrug-induced Skin EruptionsDupilumab ResponseImmunosuppressive Drug TherapyInjection Site Irritation
Dupilumab is a selectively immunosuppressive biologic therapy that treats chronic moderate-to-severe atopic dermatitis through inhibiting signaling transmission of interleukins (IL) 4 and 13. It is often prescribed when patients do not respond to or cannot tolerate conventional topical or systemic therapies. Most commonly reported side effects include injection site reactions, eye and eyelid inflammation, and nasopharyngitis.1,2 This case report highlights a patient who experienced drug-induced alopecia at 18 weeks on dupilumab.
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson, Thomas Bieber, Emma Guttman‐Yassky et al. · New England Journal of Medicine · 2016 · 2K citations · Full text
Medicine, Dermatology, Immunology +12
Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
Lisa A. Beck, Diamant Thaçi, Jennifer D. Hamilton et al. · New England Journal of Medicine · 2014 · 1.4K citations
Medicine, Dermatology, Immunology +13
Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Chizuko Koga, Kenji Kabashima, Noriko Shiraishi et al. · Journal of Investigative Dermatology · 2008 · 672 citations · Full text
Medicine, Dermatology, Immunology +16