AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mtext mathvariant="bold">κ</mml:mtext></mml:mrow></mml:math>B Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats

Abstract

The BDL model of hepatic cholestatic injury resulting in activation of Kupffer cells and recruitment of immune cells might initiate an inflammatory response through activation of the NF-<i>κ</i>B pathway. The AMPK activator AICAR significantly alleviated BDL-induced inflammation in rats by mainly inhibiting the noncanonical NF-<i>κ</i>B pathway and thus protecting against hepatic injury and fibrosis triggered by BDL.