Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non‐Tumor Liver

Abstract

Unsupervised analysis revealed two main clusters: cluster 1 contained most of the iCC_C while cluster 2 was divided in 2 subgroups, one containing most of the iCC_N and the other regrouping CC_H and CC_P . Compared to iCC_N , iCC_C displayed upregulation of molecules involved in cell adhesion, motility and angiogenesis. Epithelial markers associated with secretory pathway and fibroblast markers were overexpressed in CC_H compared to iCC_N CONCLUSION AND CLINICAL RELEVANCE: This study demonstrated that iCC_C is a specific entity, suggesting a major impact of the background liver on tumor biology, and confirmed that extrahepatic CCs define a homogeneous subgroup.