Room-temperature Pd(<scp>ii</scp>)-catalyzed direct C–H TIPS-ethynylation of phenylacetic amides with terminal alkynes

Abstract

Ligand-promoted Pd(<sc>ii</sc>)-catalyzed direct C–H alkynylation of phenylacetic amides has been developed, where 8-aminoquinoline was employed as a removable bidentate auxiliary, giving rise to optically pure ortho-alkynylated α-APA.