Effects of Sacubitril/Valsartan on Neprilysin Targets and The Metabolism of Natriuretic Peptides in Chronic Heart Failure: A Mechanistic Clinical Study

Abstract

Sacubitril/valsartan rapidly and strongly reduced sNEP activity, leading to an increase in levels of NEP substrates. These data suggest a pleiotropic favourable impact of sacubitril/valsartan on the metabolism of HF patients with ANP rather than BNP as major effectors amongst natriuretic peptides.