Activating Mutations in <i>Pik3ca</i> Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes - Concepedia

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Activating Mutations in <i>Pik3ca</i> Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes

30

Citations

40

References

2018

Year

Myeong-Kyun Shin, Susan Payne, Andrea Bilger, Kristina A. Matkowskyj, Evie H. Carchman, Dominique S. Meyer, Mohamed Bentires‐Alj, Dustin A. Deming, Paul F. Lambert

Clinical Cancer Research

Abstract

These data demonstrate that activating mutations in <i>Pik3ca</i> drive anal carcinogenesis together with HPV16 oncogenes, and that the PI3K/mTOR pathway is a relevant target for therapeutic intervention.

References

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