Journal of Biochemical and Molecular Toxicology · 2018 · 15 citations · 28 references
PharmacyNeuroscienceToxicologyDevelopmental NeuroscienceMolecular NeuroscienceNeurodegenerationCadmium ToxicologyCentral Nervous System ToxicityEnvironmental Heavy Metal ExposureHeavy Metal NeurotoxicityMetal ToxicityNeurotoxicity MechanismsCadmium Developmental ToxicityCadmium Toxicity MechanismsEnvironmental Cadmium ExposureHeavy Metal ExposureNeural ProliferationNoncanonical Hedgehog SignalingOxidative BalanceOxidative Dna Damage
BACKGROUND: Cadmium is a nonessential toxic heavy metal, which enters the body easily and damages the cellular system. The sonic hedgehog (Shh) signaling pathway is one of the key regulatory pathways, which define neural growth and development. OBJECTIVES: This study aimed to explore how cadmium exposure affects neural activities, Shh signaling cascade, and its downstream target genes. METHODS: Total 18 male Wistar rats were randomly divided into two groups, control and test groups. Test rats were administered with 3 mg cadmium/kg body weight, while the control rats were treated with vehicle continuously for 28 days. Thereafter, rats were killed and the isolated brain samples were examined using oxidative stress assessment, histological and immunohistological behavioral assessment, polymerase chain reaction (PCR), and the comet assay. RESULTS: A disturbed oxidative balance, DNA damage, and an upregulated Shh signaling pathway were observed in cadmium-treated samples. Loss of structural integrity in cerebellum and loss of motor activity were observed in cadmium-treated rats.
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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn, Carol Wicking, Peter G. Zaphiropoulos et al. · Cell · 1996 · 2K citations · Full text