Reactions of aminopyrimidine derivatives with chloroacetyl and isophthaloyl chlorides

Abstract

Abstract 1‐Aminopyrimidine‐2‐one derivatives ( 1a‐c ) were prepared in two steps from furan‐2,3‐diones and semicarbazones in toluene/benzene. Pyrimidin‐[1(2 H )‐yl] acetamide derivatives and isophthalimide derivatives were synthesized from the nucleophilic acyl substitution reactions of compounds 1a‐c with chloroacetyl chloride. The structures of compounds 2a‐f were verified by IR , 1 H NMR , 13 C NMR and elemental analyses. The obtained final organic compounds were tested as catalysts in the Mizoroki‐Heck coupling reaction. They mostly exhibited very high catalytic activity results for the coupling reaction of styrene with different aryl bromide derivatives.