Publication | Open Access
Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane
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Citations
17
References
2018
Year
Elusive Pentavalent PhosphoraneProtide Prodrugs ActivationMedicinal ChemistryEngineeringReactive Cyclic IntermediatesBiochemistryCyclic Phosphorus IntermediatesNatural SciencesMechanism Of ActionBiochemical InteractionOrganic ChemistryIrpd SpectroscopyChemical BiologyPharmacologyProtein PhosphorylationBiomolecular Engineering
A combination of NMR and IRPD spectroscopy confirmed the existence of predicted cyclic phosphorus intermediates involved in ProTide prodrugs activation.
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