Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by <i>Clostridium perfringens</i> type C

Abstract

As a result, 2,056 novel lncRNAs and 2,417 differentially expressed genes were found. These lncRNAs shared the same characteristics of fewer exons and shorter length. Bioinformatics analysis identified that two lncRNAs (<i>ALDBSSCT0000006918</i> and <i>ALDBSSCT0000007366</i>) may be involved in five immune/inflammation-related pathways (such as Toll-like receptor signaling pathway, MAPK signaling pathway, and Jak-STAT signaling pathway), which were associated with resistance and susceptibility to <i>C. perfringens</i> type C infection. This study contributes to the understanding of potential mechanisms involved in the immune response of piglets infected with <i>C. perfringens</i> type C.