Myelin loss in white matter hyperintensities and normal-appearing white matter of cognitively impaired patients: a quantitative synthetic magnetic resonance imaging study

Abstract

• Quantitative synthetic MRI allows simultaneous acquisition of conventional MRI and myelin quantification without additional scanning time. • Normal-appearing and hyperintense white matter demonstrate myelin loss in cognitively impaired patients. • This myelin loss partially explains cognitive dysfunction in patients with cognitive complaints.