Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice

Abstract

The ICCs are mainly distributed in the proximal colon and there are more PDGFRα⁺ cells are in the distal colon, which generates a pressure gradient between the two ends of the colon to propel the feces to the anus.