Kaurenoic Acid and its Sodium Salt Derivative: Antibacterial Activity Against <i>Porphyromonas Gingivalis</i> and their Mechanism of Action

Abstract

Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria. Proteomic analysis suggested that these compounds might interfere in bacterial metabolism and virulence factor expression. Kaurane-type diterpenes are an important class of natural products and should be considered in the search for new irrigating solutions to treat endodontic infections.