Palladium-Catalyzed Intermolecular Dehydrogenative Carboamination of Alkenes with Amines and <i>N</i>-Substituted Isatin

Abstract

The first intermolecular dehydrogenative carboamination of alkenes with aromatic amines and N-substituted isatin has been developed using palladium as a catalyst. This multicomponent reaction is a valuable synthetic tool for difunctionalization of the alkene with retention of the C-C double bond. This reaction has two very distinguishing features: (1) the formation of the C-N and C-C bonds with retention of the double bond and (2) high regioselectivity. Thus, this strategy has opened up a new area in chemistry.