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Publication | Open Access

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

DOIFull Paper Access

24

Citations

49

References

2018

Year

Svenja Plöhn, Bärbel Edelmann, Lukasz Japtok, Xingxuan He, Matthias Hose, Wiebke Hansen, Edward H. Schuchman, Anja Eckstein, Utta Berchner‐Pfannschmidt
Investigative Ophthalmology & Visual Science

Abstract

The results demonstrated that CD40 ligand stimulates GO fibroblast to produce S1P, which is a driving force for T-cell migration. The results support the use of S1P receptor signaling modulators in GO management.

References

YearCitations

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