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Publication | Open Access

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

DOIFull Paper Access

95

Citations

42

References

2019

Year

Jing Li, Kyungho Kim, Si‐Yeon Jeong, Joyce Chiu, Bei Xiong, Pavel A. Petukhov, Xiangrong Dai, Xiaoyi Li, Robert K. Andrews, Xiaoping Du,
Circulation

Abstract

Our results demonstrate that PDI-facilitated cleavage of the allosteric disulfide bonds tightly regulates GPIbα function, promoting platelet-neutrophil interactions, vascular occlusion, and tissue damage under thromboinflammatory conditions.

References

YearCitations

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