Concepedia

Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of <i>N</i>-Methyl-D-Aspartate Receptors

Che Aishah Nazariah Ismail, Rapeah Suppıan, Che Badariah Abd Aziz, Khalilah Haris, Idris Long

Diabetes & Metabolism Journal · 2018 · 20 citations · 32 references

DOIFull text

Open access

Abstract

We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.

References

32

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

David Dubuisson, Stephen G. Dennis · Pain · 1977 · 2.5K citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

Keith Williams · Molecular Pharmacology · 1993 · 851 citations

Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain

Christine Courteix, Alain Eschalier, J Lavarenne · Pain · 1993 · 447 citations

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

S. Boyce, A. C. Wyatt, J.K. Webb et al. · Neuropharmacology · 1999 · 336 citations

, , +14

Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

Wei Feng, Guo‐Du Wang, Geoffrey A. Kerchner et al. · Nature Neuroscience · 2001 · 326 citations

, , +7