T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia

Abstract

The overall detection rate of <i>TCR</i> clonality was 74.5%. Survival did not differ by <i>TCR</i> clonality or immunophenotype and age group. Fragment analysis of <i>TCR</i> rearrangement cannot be used to assess MRD due to low sensitivity. Further research on the relationship between prognosis and frequency of <i>TCR</i> rearrangements is needed, using more sensitive methods to detect clonality and monitor MRD.