Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

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Medicine, Developmental Biology, Molecular Biology +17

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways

Elena J. Moerman, Kui Teng, David A. Lipschitz et al. · Aging Cell · 2004 · 852 citations · Full text

Medicine, Cell Biology, Developmental Biology +17

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis

Xiaodong Li, Michael S. Ominsky, Kelly Warmington et al. · Journal of Bone and Mineral Research · 2008 · 784 citations

Medicine, Biochemistry, Endocrinology +16

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

Desmond Padhi, Graham Jang, Brian Stouch et al. · Journal of Bone and Mineral Research · 2010 · 783 citations

Pharmacy, Pharmacokinetics, Pharmacotherapy +17

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Pirow Bekker, Donna Holloway, Amy S Rasmussen et al. · Journal of Bone and Mineral Research · 2004 · 767 citations · Full text

Pharmacy, Clinical Sciences, Pharmacotherapy +17