Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective<scp>MRI</scp>study

Abstract

These are the first prospective data on weight gain and neuroprogression in BDI. CSWG predicted neuroprogression, and neuroprogression predicted a worse clinical illness course. Trials of weight loss interventions are needed to confirm the causal direction of the weight gain-neuroprogression relationship, and to determine whether weight loss is a disease-modifying treatment.