Copy number variation of <i>LINGO1</i> in familial dystonic tremor

Abstract

The identification of a genomic duplication as the likely molecular cause of this condition, resulting in an additional <i>LINGO1</i> gene copy in affected cases, adds further support for a causal role of this gene in tremor disorders and implicates increased expression levels of <i>LINGO1</i> as a potential pathogenic mechanism.