A new antimicrobial sesquiterpene isolated from endophytic fungus <i>Cytospora</i> sp. from the Chinese mangrove plant <i>Ceriops tagal</i>

Abstract

Chemical examination of Chinese mangrove <i>Ceriops tagal</i> endophytic <i>Cytospora</i> sp., yielded a new biscyclic sesquiterpene seiricardine D (<b>1</b>), and eight known metabolites, xylariterpenoid A (<b>2a</b>), xylariterpenoid B (<b>2b</b>) and regiolone (<b>3</b>) 4-hydroxyphenethyl alcohol (<b>4</b>), (22<i>E</i>, 24<i>R</i>)5, 8-epidioxy-5α, 8α-ergosta-6,22<i>E</i>-dien-3ß-ol (<b>5</b>), (22<i>E</i>, 24<i>R</i>)5, 8-epidioxy-5α, 8α-ergosta-6,9(11), 22-trien-3 ß-ol (<b>6</b>), ß-sitosterol (<b>7</b>) and stigmast-4-en-3-one (<b>8</b>). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. The antimicrobial activities of compounds <b>1-8</b> and their effects on a panel of plant and human pathogens were evaluated.