C₃N₄ Nanosheets/Metal–Organic Framework Wrapped with Molecularly Imprinted Polymer Sensor: Fabrication, Characterization, and Electrochemical Detection of Furosemide

Abstract

Zeolite imidazole skeleton material 8 (ZIF-8) has high porosity and specific surface area, excellent water stability, and is convenient to synthesize. In this study, an original electrochemical imprinting sensor based on the modified glassy carbon electrode (GCE) with C3N4 nanosheets and framework ZIF-8 combined with MIP (ZIF-8@MIP) is developed for the sensitive detection of furosemide. MIP was formed by precipitation polymerization of ZIF-8 with furosemide as a template and methacrylic acid (MAA) as a monomer, and furosemide was detected by differential pulse voltammetry (DPV).Under the optimized conditions, the DPV response of C3N4/ZIF-8@MIP/GCE to furosemide was linear at 0.08–100 μM, with the detection limit as low as 8 nM (S/N = 3). The sensor exhibits good selectivity, high sensitivity, superior stability, and reproducibility. Thus, this method possesses high potential for the detection of furosemide in human urine specimens and furosemide tablets.