Infant Electroencephalogram Coherence and Toddler Inhibition are Associated with Social Responsiveness at Age 4

Abstract

Previous work has suggested that individual differences in infant functional neuroconnectivity are a potential biomarker for later cognitive and social outcomes, but the mechanisms are unclear. This study investigated a longitudinal model of infant frontotemporal electroencephalogram (EEG) coherence predicting toddler inhibition, which then predicted childhood social responsiveness. A structural equation model showed good fit, with increased right hemisphere frontotemporal EEG coherence predicting less inhibition at age two, which in turn predicted less social responsiveness at age four. These findings support the hypothesis that infant frontotemporal connectivity is indirectly associated with later social behavior, with toddler inhibition as a potential mechanism.