Theranostics · 2018 · 77 citations · 40 references
MedicineBiochemistryMolecular BiologyCircadian RhythmsDrug MetabolismMolecular ToxicologyCircadian Gene ExpressionCircadian Regulation Of MetabolismCytochrome P450 EnzymesCytochrome P450-mediated MetabolismHepatotoxicity MechanismsXenobiotic MetabolismCircadian ClocksCytochrome P450 Enzyme ActivityCytochrome P450 Enzyme InductionCytochrome P450 Expression RegulationCytochrome P450 Metabolic PathwaysCytochrome P450 ModulationCytochrome P450 PathwaysXenobiotic Detoxification
The role of small heterodimer partner (SHP) in regulation of xenobiotic detoxification remains elusive. Here, we uncover a critical role for SHP in circadian regulation of cytochromes P450 (CYPs) and drug-induced hepatotoxicity. Methods: The mRNA and protein levels of CYPs in the livers of wild-type and SHP -/-mice were measured by quantitative real-time polymerase chain reaction and Western blotting, respectively. Regulation of CYP by SHP was investigated using luciferase reporter, mobility shift, chromatin immunoprecipitation, and/or co-immunoprecipitation assays.
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Dec1 and Dec2 are regulators of the mammalian molecular clock
Sato Honma, Takeshi Kawamoto, Yumiko Takagi et al. · Nature · 2002 · 704 citations