Citrullinated Aggrecan Epitopes as Targets of Autoreactive <scp>CD</scp>4+ T Cells in Patients With Rheumatoid Arthritis

Abstract

Our findings indicate that T cells that recognize citrullinated aggrecan are present in patients with RA and correlate with antibodies that target this same antigen. Consequently, aggrecan-specific T cells and antibodies are potentially relevant markers that could be used to monitor patients with RA or at-risk subjects.