Empagliflozin Reduces Ca/Calmodulin-Dependent Kinase II Activity in Isolated Ventricular Cardiomyocytes

Abstract

We show for the first time that empagliflozin reduces CaMKII activity and CaMKII-dependent SR Ca²⁺ leak. Reduced Ca²⁺ leak and improved Ca²⁺ transients may contribute to the beneficial effects of empagliflozin in HF.