Science · 2018 · 373 citations · 32 references
Life SciencesNeurobiologyNeuroscienceBehavioral NeuroscienceNeurophysiologySystems NeuroscienceBrainstem CircuitsBrainstem SystemsSleep PhysiologySleep-wake NeurobiologySleep-wake RegulationThalamocortical SystemsEncoding Of Sensory StimuliLimbic LobeNeuronal Control Of WakefulnessParaventricular NucleusSleep-wake Cycle RegulationThalamic FunctionThalamic Relay SystemsThalamus Nuclei
The paraventricular thalamus links brainstem and hypothalamic signals to the limbic forebrain, encoding context‑dependent salience, gating sensory information, and influencing the sleep‑wake cycle. Neurons in the paraventricular thalamus encode reward, aversiveness, novelty, and surprise, and their activity—both at the population and single‑neuron level—is tightly coupled with wakefulness. Science, this issue, pp.
A close view of the paraventricular thalamus The paraventricular thalamus is a relay station connecting brainstem and hypothalamic signals that represent internal states with the limbic forebrain that performs associative functions in emotional contexts. Zhu et al. found that paraventricular thalamic neurons represent multiple salient features of sensory stimuli, including reward, aversiveness, novelty, and surprise. The nucleus thus provides context-dependent salience encoding. The thalamus gates sensory information and contributes to the sleep-wake cycle through its interactions with the cerebral cortex. Ren et al. recorded from neurons in the paraventricular thalamus and observed that both population and single-neuron activity were tightly coupled with wakefulness. Science , this issue p. 423 , p. 429
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