Preventative tracheal administration of interleukin‐27 attenuates allergic asthma by improving the lung Th1 microenvironment

Abstract

Preventative intranasal administration of IL-27 can recruit more IL-27-secreted monocytes to the airway and change the different T-cell classes in lung. The improved Th1 environment helps to alleviate Th2-mediated allergic asthma by repairing the STAT1 pathway but not the STAT4 pathway.