Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with <i>GUCY2C</i>-linked familial diarrhea

Abstract

Our results support a role of guanylate cyclase C signaling and disturbed electrolyte homeostasis in development of IBD. Furthermore, downregulation of metallothioneins in the ileal mucosa of FGDS patients may contribute to IBD development, possibly alongside effects from NOD2 risk variants.