The In Situ Sulfidation of Cu₂O by Endogenous H₂S for Colon Cancer Theranostics

Abstract

Abstract Expression of a high concentration of H 2 S is closely related to the formation of colon cancer tumors. However, only a few H 2 S‐triggered theranostics agents for colon cancer have been reported to date. Now, a turn‐on theranostics agent was developed by utilizing the in situ reaction of Cu 2 O and endogenous H 2 S at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed by this in situ reaction‐activated colon cancer theranostics method. This work established a simple and efficient strategy for both diagnosis and treatment of colon cancer with a novel trigger mechanism, which provides a new route for colon cancer theranostics based on the in situ reactions at the tumor sites.