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The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Atp Binding SitesBiochemistryAntiparasitic AgentMedicineNatural SciencesTrypanosomatid Parasite LeishmaniaParasitic ProtozoaAfrican TrypanosomiasisDead-box Helicase Eif4aChemical BiologyPharmacologyVisceral LeishmaniasisParasitologyDrug Discovery