Variants in<i>NKX2-5</i>and<i>FLNC</i>Cause Dilated Cardiomyopathy and Sudden Cardiac Death

Abstract

Two rare variants in NKX2-5 and FLNC, carried by 1 in 2400 Icelanders, cause familial DCM in Iceland. These genes have recently been associated with DCM. Given the serious consequences of these variants, we suggest screening for them in individuals with DCM and their family members, with subsequent monitoring of carriers, offering early intervention.