Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

Abstract

A novel high yielding, <i>enantio-</i> and diastereoselective protocol for the synthesis of α-allylated highly functionalised β-amino acid derivatives by adding isoxazolidin-5-ones to MBH carbonates under asymmetric phase-transfer catalysis has been developed.