Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for <i>In Vivo</i> Vascular Repair

Abstract

This study aimed at developing an amnion-based scaffold suitable for vascular tissue engineering applications and <i>in vivo</i> usage. We successfully produced a multilayered scaffold with improved biomechanical properties and biocompatibility for <i>in vivo</i> vascular implantation. Our approach not only offers an allogeneic "off-the-shelf" solution for clinical use but also it provides the possibility of personalized medicine using a patient's own amnion and stem cells for the production of tissue engineered grafts for reconstructive heart surgery.