Proceedings of the National Academy of Sciences · 2018 · 146 citations · 42 references
Life SciencesGeneticsMolecular BiologyGene ExpressionTranscriptionTranscriptional RegulationMuscle DevelopmentMuscle DifferentiationNoncoding Rna BiologyRna-protein InteractionsCrosstalk With Polycomb Repressive ComplexesDevelopmental Regulation By Noncoding RnaEpigenetic Regulation Of MyogenesisMuscle Development EpigeneticsMuscle Development GeneticsPolycomb Repressive Complex 2
Significance While numerous long noncoding RNAs (lncRNAs) have been identified in muscle, most of their roles in myogenesis remain unclear, and many more lncRNAs have yet to be identified. In this study, we identified an intronic lncRNA, SYISL ( SYNPO2 intron sense-overlapping lncRNA), which is highly expressed in muscle and interacts directly with polycomb repressive complex 2 (PRC2) to repress muscle development. The results reveal that SYISL acts as a regulatory RNA in PRC2-mediated myogenesis.
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