Recombinant Newcastle disease virus expressing human IFN‐λ1 (rL‐hIFN‐λ1)‐induced apoptosis of A549 cells is connected to endoplasmic reticulum stress pathways

Abstract

In summary, rL-hIFN-λ1 inhibited cell proliferation and activated ERS, autophagy, and apoptosis in A549 cells and tissues, and when ERS pathways were blocked, the inhibiting effect was even more pronounced. Therefore, the recombinant Newcastle disease virus rL-hIFN-λ1-induced apoptosis of A549 cells is connected to ER stress and could be a promising therapeutic agent for lung adenocarcinoma.