Copper‐Catalyzed Four‐Component Reaction for the Synthesis of <i>N</i>‐Difluoroethyl Imides

Abstract

A general and efficient method for the synthesis N ‐difluoroethyl imides has been developed. This copper‐catalyzed four‐component reaction proceeds via in‐situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late‐stage functionalization of drugs and drug‐like molecules.