The effects of amniotic membrane stem cell-conditioned medium on photoaging

Abstract

<b>Background:</b> Photoaging is a complex biologic process that affects various layers of the skin with the major damage seen in the connective tissue of the dermis. Although rarely fatal, photoaging can significantly contribute to a loss of quality of life; therefore, it deserves attention. Researchers are continually searching for new compounds to develop rejuvenation therapies. Nowadays, the stem cell population has been discovered, and it shows capability to rejuvenate the skin. <b>Material and methods:</b> This was an analytic experimental research conducted on a total of 48 women who were randomized into two groups: 24 women received amniotic membrane stem cell-conditioned medium (AMSC-CM) and the other 24 women received normal saline (NS). We applied the drug for three times with an interval of 2 weeks. Microneedling was used to enhance epidermal penetration. We evaluated the progression of photoaging on Weeks 0, 4, and 8, as well as the side effects. <b>Results:</b> The improvement in photoaging after treatment showed significant better effects with the AMSC-CM than with NS (<i>p</i> < .05). There were minimal transient side effects in either of the study groups. <b>Conclusion:</b> AMSC-CM has the capability to improve clinical photoaging and is a promising option for rejuvenation therapy.